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Organic Letters 2020, 22 (2) , 642-647. https://doi.org/10.1021/acs.orglett.9b04416; Hana Nakajima, Yuki Hazama, Yuki Sakata, Keisuke Uchida, Takamitsu Hosoya, Suguru Yoshida.
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An efficient silver catalyzed annulation reaction of aryne with nitriles to generate quinazolines is described. Arynes generated from triynes or tetraynes through a hexadehydro Diels–Alder reaction readily participated in an [A + 2B] mode of annulation with nitriles in the presence of AgSbF6 catalyst.
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